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/In Vitro Fertilization/

IVF(In Vitro Fertilization)

4st Generation IVF
test tube baby IIII
In addition to PGT-A and PGT-M, 3rd Generation IVF Max also includes the endometrial receptivity analysis (MIRA) and a 24-hour time-lapse embryo culture system to screen the embryos (euploid embryos), determine the proper time of implantation, and carry out dynamic tracking before and after implantation (antiallergic treatment, immunity, thrombosis, endometrium thickness, etc.), coupled with the assisted pregnancy treatment of traditional Chinese medicine, the success rate is thus significantly increased.
/Treatment process/
TREATMENT PROCESS
01
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Step01
Pre-treatment assessment
Anti-mullerian hormone (AMH), hormonal tests, ultrasonography.

*Based on the physician's opinion
Step02
TCM assisted treatment for IVF
Before the treatment, the doctor will assess whether to incorporate traditional Chinese medicine (TCM) for nourishing Yin and tonifying the kidneys to enhance ovarian function. Additionally, blood circulation and Qi-regulating therapy may be recommended to further improve the success rate of IVF.
Step03
Egg retrieval process
(Day 2-10 of menstruation)
Start to give ovulation stimulating injections on the 2nd/3rd days. Make follow-up appointments for ultrasonography and blood tests to check the size of follicles and the change in hormonal levels.
Step04
Giving egg retrieval injection
(Day 10-12 of menstruation)
The doctor will determine the time for injections and egg retrieval.
(Usually about 36 hours later)
Step05
Egg retrieval
(Day 12-14 of menstruation)
The subject may return home if she feels well after egg retrieval.
Step06
Embryo culture
The doctor will determine whether to perform ICSI and culture the fertilized egg until it becomes an embryo on Day 3 or enters the stage of blastula on Day 5 or 6. Experienced embryologists will then select blastocysts according to their status to take PGT-A tests.
-Biopsy testing takes approximately 20 days.
Step07
Pre-implantation examination
In addition to tests of 3rd Generation IVF (PGT-A), in GENE INFERTILITY MEDICAL CENTER, we also carry out new generation endometrial receptivity analysis (MIRA), hysteroscope examination, and thrombosis and immune tests for 3rd Generation IVF Max. WBC (anti-allergic treatment) will be performed right before the implantation to attain precise implantation and significantly increase the chance of conception.
Step08
Frozen embryo implantation
The pre-implantation process of frozen embryos will start on the 2nd/3rd day of menstruation. After the subject’s return visit to the clinic on the 9th and 14th day of menstruation, the implantation will be fulfilled on the 20th day (of menstruation).
Step09
Waiting for good news/pregnancy
(10-12 days after implantation)
After a positive result of the pregnancy test, the tocolytic process will be initiated.
 
24h Time-Lapse embryo monitoring

 

To ensure that no precious moment of their little one's growth is missed, parents always love to take photos and videos to capture every milestone.
 

At GENE INFERTILITY MEDICAL CENTER, we have considered this for all future parents. That’s why, in our laboratory, we provide a specialized environment for embryo development—an independent 24-hour Time-lapse Embryo Monitoring System (Time-lapse Culture System).
 

Using a high-resolution microscope, we continuously observe the growth of each embryo, recording key developmental stages such as cell division dynamics, morphological changes, and fragment formation. The system captures images at regular intervals, creating a detailed record of embryo development.

Most importantly, this advanced technology allows embryos to grow in a stable environment without the need for frequent movement in and out of the incubator. It enables us to closely monitor each embryo's progress in real-time, helping us select the highest-quality embryos for implantation with greater precision.

 

Two Types of 4th Generation IVF – AI-based Embryo Selection & Ni-PGTA

 

24-hour Time-lapse Embryo Incubator not only provides a safe and stable environment for embryo development but also incorporates AI-based Embryo Selection at GENE INFERTILITY MEDICAL CENTER. This advanced system continuously monitors embryo division and growth while integrating global embryo development data. Using AI-driven precise calculations, each embryo is scored and evaluated, offering embryologists a critical reference for assessing embryo quality. Additionally, AI can predict implantation potential, significantly increasing the chances of a successful pregnancy for future parents undergoing IVF treatment.
 

The second type of 4th Generation IVF technology is NiPGT-A (Non-invasive Preimplantation Genetic Testing for Aneuploidy). This technique analyzes the embryo's culture medium to examine its chromosomal status without the need for embryo biopsy, thereby reducing potential harm to the embryo. However, NiPGT-A is not yet a standard clinical practice and cannot replace traditional PGT-A at this stage. GENE INFERTILITY MEDICAL CENTER has been researching this field for years and has received an Outstanding Oral Presentation Award at a reproductive medicine conference. If NiPGT-A proves to have clinical value in the future, we will promptly integrate it into IVF treatment procedures.

 

       Note: Mitochondrial Replacement Therapy (MRT) is also sometimes referred to as 4th Generation IVF.

 

 

Conclusion

As the generations of IVF advance, the number of screening procedures has also increased. However, a higher generation does not necessarily mean better outcomes. Instead, the most suitable treatment should be determined by the doctor based on the specific health conditions of the couple undergoing the procedure.
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