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If one of the couples has a dominant or recessive non-allelic genetic disease, the chance of giving birth to a child with the same genetic disease will be 1/2 or 1/4, such as hemophilia, spinocerebellar atrophy, achondroplasia, etc. By analyzing the cells of the embryos before implantation, PGT-M / PGD can separate out chromosomes that are attributable to the related genetic diseases and obviate the possibility of inheritance of the disease.

Thanks to the development of technology, PGT-M/PGD can aim at a specific known genetic disease in the family and can identify a non-allelic genetic disease in a rapid manner with an accuracy of as high as 90%. However, it cannot avoid chromosomal defects, congenital abnormalities, and other genetic diseases that have not been identified in the family. Therefore, after successful conception through IVF and PGT-M/PGD screening, the expectant mother still needs to receive prenatal checkups to ensure the health of the fetus.