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04/16 2025

E2 (Estradiol) Before Starting IVF Treatment

💉What is E2 (Estradiol)?
E2 (estradiol) is an estrogen secreted by the ovaries that affects female development. It plays a crucial role during the menstrual cycle, in conception preparation, and during pregnancy. For example, it helps regulate the maturation of follicles in the ovaries and promotes egg development.
A mature follicle can secrete approximately 150–300 pg/ml of estradiol. Therefore, higher estrogen levels typically indicate a greater number of mature follicles.

💉Why is E2 (Estradiol) tested during IVF treatment?
Measuring E2 levels before entering IVF treatment is an important indicator to evaluate ovarian function and whether the body is ready to begin ovarian stimulation.
During the stimulation phase, changes in E2 levels reflect how the ovaries are responding to stimulation medication.
Normally, E2 levels steadily increase with injections during stimulation. If the growth is minimal, it may indicate that the ovaries are not responding well, which could affect the number of eggs retrieved.
If there is no response at all, it could suggest premature ovarian insufficiency, meaning there may be only one egg or even a need to cancel the cycle.
On the other hand, if E2 rises too high, there is an increased risk of OHSS (Ovarian Hyperstimulation Syndrome) after egg retrieval.
Therefore, doctors assess E2 levels through blood tests before entering treatment to determine whether it's suitable to proceed in that cycle. During stimulation, they also monitor E2 changes to precisely understand ovarian response and adjust medication dosage and treatment planning accordingly. 🧑‍⚕️

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E2 (Estradiol) Before Starting IVF Treatment

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